What are the reasons that cause of gout?

Gout is the most important biochemical basis of hyperuricemia. Normal adult daily produce about uric acid 750mg, 80% of which is endogenous, 20% of exogenous uric acid, which uric acid metabolism into the pool (about 1200mg), daily pool of uric acid metabolism metabolism of about 60 percent, About one-third through the intestinal catabolism 200mg, 2/3 of about 400mg excreted by the kidneys, which can maintain stable levels of uric acid, which can cause problems with any aspect of hyperuricemia.

1. Primary gout
Multi-hereditary, but a family history of gout clinical accounted for only 10% to 20%. Excessive uric acid production accounts for 10% of primary etiology of hyperuricemia. The main reason is a purine metabolic enzyme defect, hypoxanthine guanine phosphoribosyl transferase (HGPRT) deficiency and ribose pyrophosphate (PRPP) synthetase activity hyperthyroidism. Primary renal excretion of uric acid reduction accounts for about 90% of primary hyperuricemia specific pathogenesis is unclear, it may be polygenic disease, but should exclude organic disease kidneys.

2. Secondary gout
Refers to a clinical manifestation of secondary to other disease processes, and can also be caused by certain medications. Myeloproliferative disorders such as leukemia, lymphoma, multiple myeloma, polycythemia red blood cell count, hemolytic anemia, and cancer cell proliferation may result in accelerated, so that the nucleic acid conversion increases, resulting in increased production of uric acid. Malignant tumor after chemotherapy caused extensive damage cells, nucleic acid conversion also increased, leading to increased production of uric acid. Kidney disease, including chronic glomerulonephritis, pyelonephritis, polycystic kidney disease, lead poisoning and hypertension, late loss caused by glomerular filtration, can reduce uric acid excretion, leading to elevated serum uric acid concentrations. Drugs such as thiazide diuretics, furosemide, ethambutol, pyrazinamide, low-dose aspirin and niacin, can competitively inhibit renal tubular excretion of uric acid caused by hyperuricemia. In addition, long-term kidney transplant patients taking immunosuppressive drugs may also occur hyperuricemia, may be associated with immunosuppression related to inhibition of renal excretion of uric acid.

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Article: What are the reasons that cause of gout?

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